000			01718 a2200193 4500
005			20250917163336.0
008			250115b |||||||| |||| 00| 0 eng d
020			_a9781783629924
041			_aeng
082			_a616.99 _bWarD
100			_aWaring, Michael J
245			_aDNA Targetting Molecules as Therapeutic Agents / _cMichael J Waring
260			_aLondon : _bRoyal Society of Chemistry, _c©2018.
300			_a414p.
490			_aChemical Biology
520			_aThere have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.
650			_aTechnology _xMedicine & health
942			_cBK
999			_c7226 _d7226