000			01886 a2200205 4500
005			20251114154625.0
008			241226b |||||||| |||| 00| 0 eng d
020			_a9781782625285
041			_aeng
082			_a572.65 _bKoeC
245			_aCyclic Peptides : _bFrom Bioorganic Synthesis to Applications / _cedited by Jesko Koehnke , James Naismith and Wilfred A van der Donk
260			_aLondon : _bRoyal Society of Chemistry, _c©2018.
300			_axii, 379p.
520			_aCyclic peptides are increasingly employed as chemical tools in biology and drug discovery. They have gained a lot of interest as alternative sources of new drugs to traditional small molecules. This book introduces cyclic peptides and provides a thorough overview of biosynthetic and fully synthetic approaches to their preparation. Following an introduction to cyclic peptides, biosynthetic and traditional chemical routes to cyclic peptides are reviewed. Due to their size, their synthesis is not trivial. Recent advances in the incorporation of novel structural units are presented in addition to how synthesis and biological methods can be combined. The chemical analysis of this molecular class is also discussed. Furthermore, chapters detail the progression of cyclic peptides as tools in biology and as potential drugs, providing a future vision of their importance. In total, this book provides the reader with a comprehensive view of the state-of-the-art of cyclic peptides, from construction to possible clinical utility. This book will be an essential resource for students, researchers and scientists within industry in medicinal, bioorganic, natural product and analytical chemistry fields.
650			_aScience _xFrom bioorganic synthesis to applications
700			_aKoehnke, Jesko [Ed.]
700			_aNaismith, James [Ed.]
700			_aDonk, Wilfred A van der [Ed.]
942			_cBK
999			_c7227 _d7227