000			01451nam a2200229 4500
005			20251016235829.0
008			241226b |||||||| |||| 00| 0 eng d
020			_a9781118028964
041			_aeng
082			_a572.62 _bHamP
100			_aHam, Bryan M.
245			_aProteomics of Biological Systems : _bProtein Phosphorylation Using Mass Spectrometry Techniques / _cBryan M. Ham
260			_aNew Jersey: _bJohn Wiley & Sons; _c©2012
300			_axxiii, 350p.
520			_aPhosphorylation is the addition of a phosphate (PO4) group to a protein or other organic molecule. Phosphorylation activates or deactivates many protein enzymes, causing or preventing the mechanisms of diseases such as cancer and diabetes. This book shows how to use mass spectrometry to determine whether or not a protein has been correctly modified by the addition of a phosphate group. It also provides a combination of detailed, step-by-step methodology for phosphoproteomic sample preparation, mass spectral instrumental analysis, and data interpretation approaches. Furthermore, it includes the use of bioinformatic Internet tools such as the Blast2GO gene ontology (GO) tool, used to help understand and interpret complex data collected in these studies.
650			_aProteomics _xMethodology
650			_aPhosphorylation _xMethodology
650			_aBiological Systems
650			_aPhosphoproteins _xSynthesis
650			_aMass Spectrometry
942			_cBK
999			_c7252 _d7252